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The dermo-epidermal junction was not well-maintained. The dermis showed moderately dense lympho-histiocytic infiltrate.
This was suggestive of fairly well-differentiated SCC [Figure 5] and [Figure 6].
It metastasizes most often to the lungs, bones, and liver.
Skin involvement originating from cervical cancer is rare, even in the terminal stages of the disease.
Indian J Dermatol [serial online] 2015 [cited 2018 Feb 5];0-2. 2015/60/6/600/169134A 50-year-old postmenopausal female presented to dermatology clinic of Government Medical College with complaints of skin lesions on genitalia with pain in vulval region, and dyspareunia for 6 months; and yellowish-white foul smelling discharge per-vaginum for past 2-3 months.
Neither she nor her spouse had a history suggestive of high-risk behavior or sexually transmitted infection (STI).
At the time of presentation, the average age was 52 years (23-79 years) and most common FIGO clinical stage was Stage IIIB.
Average interval between diagnosis and appearance of cutaneous metastasis based on stage was 37.6 months (Stage I), 20.8 months (Stage II), 24.9 months (Stage III) and 3.4 months (stage IV).
Hematogenous dissemination and distant metastasis are rare.
Serum creatinine was 4.5 mg%, blood urea 109 mg%, serum bilirubin 0.4 mg%; and serum HIV and serum venereal disease research laboratory were negative.
Incision biopsy from cervix was suggestive of large cell keratinizing squamous cell carcinoma (SCC) [Figure 3] and [Figure 4].
Clinical differential diagnoses were carcinoma cervix Stage IIB with cutaneous metastasis; granuloma inguinale or lymphogranuloma venereum (ruptured inguinal bubo) in an immunocompromised case.
On investigation, her hemoglobin was 9 g%; her complete blood count and urine routine-microscopy were within normal limits.