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Triple Sulfa is often a good choice when there is an infection caused by a scrape, abrasion, or similar.
While not often the first choice for fish eye issues, including pop-eye, it can be a first choice or a second choice if the first choice fails in treating such maladies involving the eye.
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Sulfas are still one of the better anti-microbials for wounds or large sores (Nitrofurazone and Neomycin are other potential choices or possible combinations).
Use in combination with Neomycin for stubborn sores, in particular lower p H aquariums/ponds is also a consideration.
Animal cells are unable to synthesize folic acid and it must be provided in the diet.
For this reason sulfa drugs are not toxic to animal cells.